Patent Application

China Mainland

Overview of biosynthetic fur technology

1. Through woolisation process (woolization), the fur animal hair is combed and stripped to obtain needle hair and down, according to the proportion of needle hair and down distribution of different animals (mink, for example, the ratio of needle hair and down is 1:60~1:70) and the number of needle hair distribution per unit area (mink, for example, 479-540 roots / square centimetre) to get the hair tufts (mink, for example, 500 tufts / square centimetre, each tuft has 1 needle hair and 65 down hair) evenly distributed in a net-like manner within the unit area. tufts/cm2 , 1 needle hair per tuft, 65 downy hairs) were evenly distributed in the unit area according to the mesh, and each tuft was integrated by using tissue sheath (Connective tissue sheath, CTS fibroblasts), and this was used as the medium for each cell of the skin and gallbladder.
2. Stem cells are extracted from the blood of fur animals and reprogrammed to an embryonic-like pluripotent state (i.e., iPSC induced pluripotent stem cells), and the induced pluripotent stem cells are used for the directional synthesis of various types of keratinocytes and fibroblasts required for the composition of the epidermis and dermis, and the cells required for biosynthesis of fur are optimised and streamlined according to the application of different skins and hides (for example, for the application of real mink fur). (Mink for example, the real mink fur application will eliminate a lot of fat in the hypodermis hypo-dermis, so this kind of directional synthesis can be screened to eliminate fat, blood vessels, etc.) and according to the real situation of various animals to arrange the combination of the required cells in the hair cluster culture medium and grow in this way.
3. Epidermis main synthesis cells (from outside to inside)
   Stratum corneum – 5 to 15 layers of flat, non-nucleated cells
   Hyaline layer – flatter cells
   Granular layer – flat cells
   Echinocyte layer – spiny cells
   Basal layer – single layer of columnar cells
4. Main synthetic cells and fibres of the dermis
   Collagen fibres
   Reticular fibres
   Elastic fibres
   Matrix – proteoglycans
5. According to the specific situation of growth and development, waiting for there is obvious cell layering, and finally using the nitro system process, to get the biosynthetic fur.
   Patent advantage: through the patent, fur products from the performance of biomimetic and other aspects will be no different from real leather products, compared with the traditional artificial fur, for the environment and ecological pollution is extremely small (almost no), while reducing animal killing, and can maintain part of the original industry employment and the rights and interests of breeding animals (traditional fur animal hair wool use, a conservative estimate of the impact of China’s 7 million people employed in the industry)